Empagliflozin Impurity 291 CAS CATO-C4X-1065291
| CAS No. | CATO-C4X-1065291 |
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Empagliflozin Impurity 291 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Empagliflozin Impurity 291 (CAS CATO-C4X-1065291, C18H18ClIO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Empagliflozin Impurity 291 (C18H18ClIO2) is characterized by a steroid core, a hydroxyl group, an ether linkage, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H18ClIO2 |
| Molecular Weight | 428.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin impurity 266 (CAS CATO-C4X-1065266)
- Empagliflozin impurity 267 (CAS CATO-C4X-1065267)
- Empagliflozin impurity 268 (CAS CATO-C4X-1065268)
- Empagliflozin impurity 269 (CAS CATO-C4X-1065269)
- Empagliflozin Impurity 289 (CAS CATO-C4X-1065289)
- Empagliflozin Impurity 290 (CAS CATO-C4X-1065290)
- Empagliflozin Impurity 311 (CAS CATO-C4X-1065311)
- Empagliflozin Impurity 312 (CAS CATO-C4X-1065312)
Recommended Standards
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- Pinaverium Impurity 2 (CAS 3647-69-6)
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- 1-(8-Methyl-3-quinolyl)ethanone (CAS 1516675-27-6)
- L-Arabinose hydrazone (CAS 816-01-3)
- 3-Isopropyladamantane-1-carboxylic acid (CAS 26847-09-6)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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