Empagliflozin Impurity 277 CAS CATO-C4X-1065277
| CAS No. | CATO-C4X-1065277 |
| Molecular Formula | C18H18BrClO2 |
| Molecular Weight | 381.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 381.69 g/mol gives Empagliflozin Impurity 277 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Empagliflozin Impurity 277 (CAS CATO-C4X-1065277) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18BrClO2 and a molecular weight of 381.69 g/mol.
Structurally, Empagliflozin Impurity 277 (C18H18BrClO2) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 381.69 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Empagliflozin Impurity 277 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18BrClO2 |
| Molecular Weight | 381.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 276 (CAS CATO-C4X-1065276)
- Empagliflozin Impurity 279 (CAS CATO-C4X-1065279)
- Empagliflozin Impurity 104 (CAS 915095-84-0)
- Empagliflozin impurity 182 (CAS 915095-83-9)
- Empagliflozin impurity 226 (CAS CATO-C4X-1065226)
- Empagliflozin impurity 231 (CAS 1637561-86-4)
- Empagliflozin impurity 259 (CAS CATO-C4X-1065259)
- Empagliflozin impurity 194 (CAS CATO-C4X-1065194)
Recommended Standards
- Econazole (CAS 27220-47-9)
- Bexagliflozin Impurity 9 (CAS 1118567-45-5)
- Miconazole EP Impurity I (CAS 47363-37-1)
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- Flomoxef Impurity 20 (CAS CATO-C4X-138220)
- Ergocalciferol EP Impurity B (CAS 57-87-4)
- Rimegepant Impurity 116 (CAS CATO-C4X-2487116)
- Ethyl 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-oxoacetate (CAS 131030-47-2)
- N-((1R,5S,6s)-3-benzyl-3-azabicyclo[3.1.0]Hexan-6-yl)acetamide (CAS 232598-24-2)
- 1-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylcyclohexane-1-carboxylic acid (CAS 851307-75-0)
- 4-(2,3-Dichlorophenoxy)butanoic acid (CAS 7170-59-4)
- (4-(4-(Trifluoromethoxy)phenoxy)phenyl)methanol (CAS 1686102-84-0)
- 1-Propyl-2-sulfanyl-1h-1,3-benzodiazole-5-sulfonamide (CAS 731776-67-3)
- Polymyxin B nonapeptide TFA (CAS 2220175-42-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com