Empagliflozin Impurity 40 CAS CATO-C4X-106540
| CAS No. | CATO-C4X-106540 |
| Molecular Formula | C19H20ClFO5 |
| Molecular Weight | 382.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Empagliflozin Impurity 40.
Empagliflozin Impurity 40 (CAS CATO-C4X-106540) is a certified pharmaceutical impurity reference standard with the molecular formula C19H20ClFO5 and a molecular weight of 382.81 g/mol.
The molecular framework of Empagliflozin Impurity 40 (C19H20ClFO5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20ClFO5 |
| Molecular Weight | 382.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 44 (CAS CATO-C4X-106544)
- Empagliflozin impurity 204 (CAS 1800196-43-3)
- Empagliflozin Impurity 276 (CAS CATO-C4X-1065276)
- Empagliflozin Impurity 277 (CAS CATO-C4X-1065277)
- Empagliflozin Impurity 279 (CAS CATO-C4X-1065279)
- Empagliflozin Impurity 104 (CAS 915095-84-0)
- Empagliflozin impurity 182 (CAS 915095-83-9)
- Empagliflozin impurity 226 (CAS CATO-C4X-1065226)
Recommended Standards
- tert-Butyl((3-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)dimethylsilane (CAS 2304635-51-4)
- N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)phenyl)methanesulfonamide (CAS 338407-66-2)
- 1-((2-Chloro-6-fluorobenzyl)oxy)-2-(4-methoxyphenyl)-1H-benzo[d]imidazole (CAS 339009-76-6)
- 3-Chloro-2,2-dimethyl-N-((1-methyl-5-morpholino-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)propanamide (CAS 956739-21-2)
- Revefenacin impurity 103 (CAS 1155168-91-4)
- Isavuconazole Impurity 147 (CAS CATO-C4X-1236147)
- Valsartan Impurity 68 (CAS CATO-C4X-105768)
- 4-(((6-Nitro-4H-benzo[d][1,3]dioxin-8-yl)methyl)thio)quinazoline (CAS 869709-06-8)
- (2-Amino-2-phenylethyl)dimethylamine dihydrochloride (CAS 31788-89-3)
- N-(6-Acetyl-2H-1,3-benzodioxol-5-yl)-2-(4-methylpiperazin-1-yl)acetamide (CAS 491867-79-9)
- N-(4-(N-Phenylsulfamoyl)phenyl)acetamide (CAS 2080-33-3)
- 3-(1H-Benzo[d]imidazol-2-yl)acrylamide (CAS 51100-80-2)
- 2-(2-((Dimethylamino)methyl)pyrrolidin-1-yl)ethanamine (CAS 1310125-52-0)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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