Erlotinib impurity 141 CAS CATO-C4X-1069141
| CAS No. | CATO-C4X-1069141 |
| Molecular Formula | C20H19N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Erlotinib impurity 141 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Erlotinib impurity 141 (CAS CATO-C4X-1069141, C20H19N3O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Erlotinib impurity 141 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 385.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H19N3O3 HCl |
| Molecular Weight | 385.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
- Duloxetine 2-Naphthalenol Impurity (CAS 1346599-09-4)
- Amlodipine Impurity 111 (CAS CATO-C4X-1095111)
- Vildagliptin Impurity 11 (CAS 207557-35-5)
- 2-Amino-4-chloro-5-iodobenzonitrile (CAS 1269461-82-6)
- 1-{4-[2-(3-Piperidinyl)ethoxy]phenyl}-1-ethanonehydrochloride (CAS 1219968-14-5)
- 1-Isopropyl-1H-imidazol-4-amine (CAS 1260896-88-5)
- Methyl 4-propoxy-1H-indole-2-carboxylate (CAS 881040-23-9)
- Tert-butyl 6-bromo-3,4-dihydro-1,7-naphthyridine-1(2H)-carboxylate (CAS 2387599-38-2)
- 2-Amino-5-isobutyl-4-oxo-4,5-dihydro-1h-pyrrole-3-carbonitrile (CAS 929974-28-7)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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