Erlotinib impurity 143 CAS CATO-C4X-1069143
| CAS No. | CATO-C4X-1069143 |
| Molecular Formula | C22H22ClN3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Erlotinib impurity 143.
As a process- or degradation-related impurity, Erlotinib impurity 143 (CAS CATO-C4X-1069143, C22H22ClN3O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H22ClN3O4HCl, Erlotinib impurity 143 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 464.34 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN3O4 HCl |
| Molecular Weight | 464.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
- Betamethasone impurity 114 (CAS 72559-76-3)
- Trihexyphenidyl Impurity 14 HCl (CAS 344890-62-6 (free base))
- Clopidogrel Impurity 64 (CAS CATO-C4X-102964)
- 2-(3-Bromophenyl)-4,4-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid (CAS 1439904-13-8)
- 5-Hydroxymethyl-2-furaldehyde-13C6 (CAS 1219193-98-2)
- 3-(4-Fluorophenyl)-1H-pyrazol-5-amine hydrochloride (CAS 1025447-54-4)
- 4-Methoxy-3-methylbenzenesulfonyl chloride (CAS 84910-98-5)
- 4,4'-([1,1'-Biphenyl]-4,4'-diyl)bis(thiazol-2-amine) (CAS 438233-93-3)
- 2-(2-Methoxyethoxy)-5-nitropyridine (CAS 874492-44-1)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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