Erlotinib Impurity 144 CAS CATO-C4X-1069144
| CAS No. | CATO-C4X-1069144 |
| Molecular Formula | C15H23NO6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Erlotinib Impurity 144 (CAS CATO-C4X-1069144) is a certified pharmaceutical impurity reference standard with the molecular formula C15H23NO6HCl and a molecular weight of 349.81 g/mol.
The molecular framework of Erlotinib Impurity 144 (C15H23NO6HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H23NO6 HCl |
| Molecular Weight | 349.81 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
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- 2-(2-Oxopyrrolidin-1-yl)-2-phenylacetic acid (CAS 60729-82-0)
- 2-(5-Methylpyrimidin-2-Yl)Ethan-1-Amine Hydrochloride (CAS 1781140-04-2)
- 2-(Tetrahydrofuran-2-yl)pyrimidine-5-carboxylic acid (CAS 1092291-25-2)
- Benzyl piperidine-2-carboxylate (CAS 38068-75-6)
- 2-Bromo-7-(trifluoromethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one (CAS 1821016-40-3)
- Palmitoyl Hexapeptide-12 (CAS 171263-26-6)
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