Erlotinib Impurity 146 CAS CATO-C4X-1069146
| CAS No. | CATO-C4X-1069146 |
| Molecular Formula | C21H20ClN3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Erlotinib Impurity 146.
CATO supplies Erlotinib Impurity 146 (CAS CATO-C4X-1069146), a pharmacopoeial impurity reference standard (molecular formula C21H20ClN3O3HCl, MW 434.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Erlotinib Impurity 146 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 434.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H20ClN3O3 HCl |
| Molecular Weight | 434.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
- Peptide Impurity 06 (CAS CATO-CPTD788806)
- Mirtazapine EP Impurity D (CAS 61337-68-6)
- Regorafenib Impurity 61 (CAS 327-78-6)
- N-(1-(5-((ethylamino)methyl)-1,2,4-oxadiazol-3-yl)cyclopentyl)acetamide (CAS 1171310-56-7)
- 9,9',9'',9'''-((6-Phenyl-1,3,5-triazine-2,4-diyl)bis(benzene-5,3,1-triyl))tetrakis(9H-carbazole) (CAS 1685282-47-6)
- 4-(2-Fluoro-4-nitrophenoxy)-7-hydroxy-6-methoxyquinoline (CAS 479690-08-9)
- 4-Bromo-5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one (CAS 1823870-64-9)
- 5-Bromo-2-ethylaniline (CAS 14922-91-9)
- Methyl 2-chloro-5-(5-formylfuran-2-yl)benzoate (CAS 355368-67-1)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com