ErlotiniB impurity 36 CAS CATO-C4X-106936
| CAS No. | CATO-C4X-106936 |
| Molecular Formula | C14H16Cl2N2O4 |
| Molecular Weight | 347.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of ErlotiniB impurity 36 (C14H16Cl2N2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
ErlotiniB impurity 36 (CAS CATO-C4X-106936) is a certified pharmaceutical impurity reference standard with the molecular formula C14H16Cl2N2O4 and a molecular weight of 347.19 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H16Cl2N2O4 |
| Molecular Weight | 347.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related ErlotiniB Standards
- Erlotinib Impurity 145 (CAS 1683583-42-7)
- Erlotinib Impurity 69 (CAS CATO-C4X-106969)
- Erlotinib Impurity 70 (CAS CATO-C4X-106970)
- Erlotinib Impurity 88 (CAS 18193-72-1)
- Erlotinib Impurity 22 (CAS CATO-C4X-106922)
- Erlotinib Impurity 73 (CAS CATO-C4X-106973)
- Erlotinib Impurity 74 (CAS CATO-C4X-106974)
- Erlotinib Impurity 51 (CAS CATO-C4X-106951)
Recommended Standards
- tert-Butyl 4-(iodomethyl)benzylcarbamate (CAS 218796-73-7)
- Ixazomib Impurity 62 (CAS CATO-C4X-126762)
- Tert-butyl (4-iodobenzyl)(methyl)carbamate (CAS 773128-23-7)
- (2E)-3-(3-Bromophenyl)-1-(2,5-dimethoxyphenyl)prop-2-en-1-one (CAS 1002849-71-9)
- Cetirizine EP Impurity F (CAS 83881-53-2)
- Adapalene Impurity 11 (CAS CATO-C4X-180911)
- Tryptophan impurity 32 (CAS 2306500-74-1)
- 5-Amino-6-isopropoxypyridin-2-ol (CAS 1094858-74-8)
- 4-(tert-Butyl)-6-chloro-2-(1-chloroethyl)pyrimidine (CAS 1330755-15-1)
- N-(6-(1H-Imidazol-1-yl)pyrimidin-4-yl)-3-cyanobenzamide (CAS 1448037-05-5)
- 5-Chloro-2-indolizinecarboxylic acid (CAS 1620570-06-0)
- Vazegepant Impurity 9 (CAS CATO-C4X-32009)
- 1-(Benzo[d][1,3]dioxol-4-yl)ethan-1-one (CAS 33842-14-7)
- Liraglutide Impurity 26 (CAS CATO-C4X-199226)
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