Tenofovir disoproxil Impurity 78 CAS CATO-C4X-107678
| CAS No. | CATO-C4X-107678 |
| Molecular Formula | C8H10ClN5 |
| Molecular Weight | 211.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 211.65 g/mol gives Tenofovir disoproxil Impurity 78 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Tenofovir disoproxil Impurity 78 (CAS CATO-C4X-107678) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10ClN5 and a molecular weight of 211.65 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tenofovir disoproxil Impurity 78 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 211.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tenofovir disoproxil Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10ClN5 |
| Molecular Weight | 211.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir Alafenamide Impurity 48 (CAS 50615-40-2)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir disoproxil Impurity 143 (CAS CATO-C4X-1076143)
- Tenofovir disoproxil Impurity 89 (CAS 2307-69-9)
- Tenofovir disoproxil Impurity 88 (CAS 80-40-0)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
- Tenofovir alafenamide impurity N1 (CAS 16958-60-4)
- Tenofovir Impurity 110 (CAS 20776-34-5)
Recommended Standards
- N'-(6-chloropyridin-2-yl)cyclopropanecarbohydrazide (CAS 478064-08-3)
- N-(3-Chlorophenyl)-N-(diaminomethylene)guanidine (CAS 48144-44-1)
- Suvorexant Impurity 9 (CAS 2762965-06-8)
- 6-chloro-N,N,1-trimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 2572069-00-0)
- Somatostatin Impurity 19 (CAS CATO-C4X-235019)
- Isavuconazole Impurity 160 (CAS CATO-C4X-1236160)
- Troxipide Impurity 14 (CAS CATO-C4X-214814)
- 1-(6-Bromobenzo[b]thiophen-2-yl)ethanone (CAS 959631-71-1)
- Carbonochloridic acid, 2-bromo-3-pyridinyl ester (CAS 1169939-52-9)
- 3-Phenyl-n-(piperidin-4-yl)propanamide (CAS 954575-19-0)
- N-[(Z)-2-[4-(4-Chlorophenyl)-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]-2-nitroethenyl]-4-methoxyaniline (CAS 400079-83-6)
- 4-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine (CAS 74420-05-6)
- 5'-Amino-4-chloro-4''-methyl-[1,1':3',1''-terphenyl]-4',6'-dicarbonitrile (CAS 104581-09-1)
- Integrin Binding Peptide trifluoroacetate salt (CAS 278792-07-7)
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