Tofacitinib Impurity 131 DiHCl CAS CATO-C4X-1079131
| CAS No. | CATO-C4X-1079131 |
| Molecular Formula | C13H20N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tofacitinib Impurity 131 DiHCl (CAS CATO-C4X-1079131, C13H20N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tofacitinib Impurity 131 DiHCl is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 240.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20N2 2*HCl |
| Molecular Weight | 240.78 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Alvimopan impurity 10 (CAS CATO-C4X-114510)
- Sertraline Impurity 76 (CAS CATO-C4X-134476)
- Etrasimod Impurity 26 (CAS CATO-C4X-321426)
- Butyl 4-(allyloxy)benzoate (CAS 6967-52-8)
- 1-((4-(Piperazin-1-yl)phenyl)sulfonyl)azepane (CAS 886506-30-5)
- 3-(1H-1,2,3-triazol-1-yl)propan-1-amine hydrochloride (CAS 1260882-68-5)
- 4-[2-(4-Bromo-2-chlorophenoxy)ethyl]piperidinehydrochloride (CAS 1219981-08-4)
- 1-(Azetidin-3-yl)-2-phenylethanone hydrochloride (CAS 1425334-95-7)
- Fluralaner Impurity 56 (CAS CATO-C4X-218056)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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