Tofacitinib Impurity 152 CAS CATO-C4X-1079152
| CAS No. | CATO-C4X-1079152 |
| Molecular Formula | C19H13ClN6O2S |
| Molecular Weight | 424.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Tofacitinib Impurity 152 (CAS CATO-C4X-1079152), a pharmacopoeial impurity reference standard (molecular formula C19H13ClN6O2S, MW 424.86 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Tofacitinib Impurity 152 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 424.86 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H13ClN6O2S |
| Molecular Weight | 424.86 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Tofacitinib Standards
- Tofacitinib Impurity 105 (CAS 2459302-85-1)
- Tofacitinib Impurity 241 (CAS CATO-C4X-1079241)
- Tofacitinib Impurity 244 (CAS 2504210-48-2)
- Tofacitinib Impurity 211 (CAS CATO-C4X-1079211)
- Tofacitinib Impurity 109 (CAS CATO-C4X-1079109)
- Tofacitinib Impurity 8 (CAS CATO-C4X-10798)
- Tofacitinib Impurity 163 (CAS CATO-C4X-1079163)
- Tofacitinib Impurity 210 (CAS CATO-C4X-1079210)
Recommended Standards
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