Tofacitinib Impurity 244 CAS 2504210-48-2

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.2504210-48-2
Molecular FormulaC22H23N9O
Molecular Weight429.48 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Tofacitinib Impurity 244 CAS 2504210-48-2 chemical structure

Description

Structurally, Tofacitinib Impurity 244 (C22H23N9O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 429.48 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Tofacitinib Impurity 244 (CAS 2504210-48-2) is a certified pharmaceutical impurity reference standard with the molecular formula C22H23N9O and a molecular weight of 429.48 g/mol.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC22H23N9O
Molecular Weight429.48 g/mol
AppearancePale yellow to yellow crystalline powder
Purity≥95%
StorageStore at room temperature, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)16.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2000
Nitrogen Atoms9

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