Tofacitinib Impurity 162 CAS CATO-C4X-1079162
| CAS No. | CATO-C4X-1079162 |
| Molecular Formula | C17H26ClN5 |
| Molecular Weight | 335.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tofacitinib Impurity 162 (CAS CATO-C4X-1079162) is a certified pharmaceutical impurity reference standard with the molecular formula C17H26ClN5 and a molecular weight of 335.87 g/mol.
The molecular framework of Tofacitinib Impurity 162 (C17H26ClN5) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H26ClN5 |
| Molecular Weight | 335.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 228 (CAS CATO-C4X-1079228)
- Tofacitinib Impurity 37 (CAS 1252883-90-1)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 39 (CAS 2459302-80-6)
- Tofacitinib Impurity 4 (CAS 477600-73-0)
- Tofacitinib Impurity 65 (CAS CATO-C4X-107965)
- Tofacitinib Impurity 238 (CAS CATO-C4X-1079238)
- Tofacitinib Impurity 239 (CAS CATO-C4X-1079239)
Recommended Standards
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