Tofacitinib Impurity 228 CAS CATO-C4X-1079228
| CAS No. | CATO-C4X-1079228 |
| Molecular Formula | C20H25N5 |
| Molecular Weight | 335.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 228 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Tofacitinib Impurity 228 (CAS CATO-C4X-1079228) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25N5 and a molecular weight of 335.45 g/mol.
The molecular framework of Tofacitinib Impurity 228 (C20H25N5) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H25N5 |
| Molecular Weight | 335.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 37 (CAS 1252883-90-1)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 39 (CAS 2459302-80-6)
- Tofacitinib Impurity 4 (CAS 477600-73-0)
- Tofacitinib Impurity 162 (CAS CATO-C4X-1079162)
- Tofacitinib Impurity 65 (CAS CATO-C4X-107965)
- Tofacitinib Impurity 32 (CAS CATO-C4X-107932)
- Tofacitinib Impurity 238 (CAS CATO-C4X-1079238)
Recommended Standards
- N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 384337-90-0)
- 2-Amino-6-(naphthalen-2-ylthio)quinazoline-4(1H)-thione (CAS 52978-99-1)
- 2-(Difluoromethyl)-5-fluoro-4-iodopyridine-3-carbonyl chloride (CAS 1807135-11-0)
- 2-(Difluoromethyl)-3-fluoro-5-iodopyridine-4-carbonyl chloride (CAS 1807135-07-4)
- Cisatracurium Besilate EP Impurity H (CAS 96946-44-0 (Absolute))
- Perindopril Impurity 12 (CAS CATO-C4X-125212)
- Dacarbazine EP Impurity A (CAS 4656-86-4)
- 1(2H)-Isoquinolinone, 6-fluoro-8-methoxy- (CAS 1956364-42-3)
- Fmoc-β-Ala-Asp(OMpe)-OH (CAS CATO-CPTD788972)
- 2-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-6-cyclopropoxy-4-(trifluoromethyl)benzonitrile (CAS 2629317-41-3)
- 2-(7-Fluoro-3-(methoxymethoxy)-8-methylnaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2791276-55-4)
- 4-(2-Chloro-6-fluorobenzamido)-1H-pyrazole-3-carboxylic acid (CAS 825619-06-5)
- Methyl (s)-2'-oxo-3,4-dihydro-1h-spiro[naphthalene-2,3'-piperidine]-6-carboxylate (CAS 2028325-01-9)
- Peptide 438 (CAS CATO-CPTD788438)
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