Tofacitinib Impurity 4 CAS 477600-73-0
| CAS No. | 477600-73-0 |
| Molecular Formula | C20H25N5 |
| Molecular Weight | 335.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C20H25N5, Tofacitinib Impurity 4 contains a nitrogen-containing heterocyclic scaffold, a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 335.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Tofacitinib Impurity 4 (CAS 477600-73-0, C20H25N5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tofacitinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H25N5 |
| Molecular Weight | 335.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 228 (CAS CATO-C4X-1079228)
- Tofacitinib Impurity 37 (CAS 1252883-90-1)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 39 (CAS 2459302-80-6)
- Tofacitinib Impurity 162 (CAS CATO-C4X-1079162)
- Tofacitinib Impurity 65 (CAS CATO-C4X-107965)
- Tofacitinib Impurity 32 (CAS CATO-C4X-107932)
- Tofacitinib Impurity 238 (CAS CATO-C4X-1079238)
Recommended Standards
- 4-Butoxy-N-(sec-butyl)naphthalene-1-sulfonamide (CAS 1007688-35-8)
- N-(2-(Dimethylamino)-2-(1-methyl-1H-pyrrol-2-yl)ethyl)-1-(m-tolyl)methanesulfonamide (CAS 1049419-28-4)
- N-Isopropyl-6-(pentyloxy)naphthalene-2-sulfonamide (CAS 1206149-75-8)
- Naratriptan (CAS 121679-13-8)
- Perampanel Impurity 26 (CAS CATO-C4X-243026)
- Dolutegravir Impurity 48 (CAS CATO-C4X-162048)
- Cefadroxil Impurity 8 (CAS CATO-C4X-12248)
- N-benzyl-N-methyl-3-nitrobenzamide (CAS 195140-22-8)
- 4-Amino-6-chloropicolinic acid (CAS 546141-56-4)
- 2-Chloro-6-fluorophenylacetic Acid (CAS 37777-76-7)
- 2,5-Diiodobenzoic acid (CAS 14192-12-2)
- (S)-Cibenzoline, >98% (CAS 103419-18-7)
- Splenopentin (CAS 75957-60-7)
- Tripeptide-10 citrulline (CAS 960531-53-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com