Tofacitinib Impurity 167 CAS CATO-C4X-1079167
| CAS No. | CATO-C4X-1079167 |
| Molecular Formula | 2*C13H19N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tofacitinib Impurity 167 (CAS CATO-C4X-1079167), a pharmacopoeial impurity reference standard (molecular formula C13H19N5HCl, MW 281.79 g/mol) used for the identification and quantification of trace impurities in APIs.
Tofacitinib Impurity 167 (C13H19N5HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 167 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C13H19N5 4*HCl |
| Molecular Weight | 281.79 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Rivastigmine Impurity N2 (CAS 894079-42-6)
- Iomeprol Impurity 10 (CAS CATO-C4X-182010)
- Ceritinib Impurity 31 (CAS CATO-C4X-104831)
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- 6-(Trifluoromethoxy)-2,3-dihydrobenzofuran-3-amine (CAS 944904-34-1)
- 2-Methyl-2,4,5,6-tetrahydro-1H-cyclobuta[f]inden-3-amine (CAS 2676863-67-3)
- 4-Bromo-1-[(2-fluorophenyl)methyl]-1h-pyrazol-3-amine (CAS 1001757-56-7)
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- 6-Amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol (CAS 943311-50-0)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com