Tofacitinib Impurity 248 CAS CATO-C4X-1079248
| CAS No. | CATO-C4X-1079248 |
| Molecular Formula | C11H18ClN5 |
| Molecular Weight | 255.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tofacitinib Impurity 248 (C11H18ClN5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Tofacitinib Impurity 248 (CAS CATO-C4X-1079248, C11H18ClN5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tofacitinib Impurity 248 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H18ClN5 |
| Molecular Weight | 255.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 11 (CAS 2227197-38-6)
- Tofacitinib Impurity 166 (CAS 923036-28-6)
- Tofacitinib Impurity 69 (CAS CATO-C4X-107969)
- Tofacitinib Impurity 74 (CAS CATO-C4X-107974)
- Tofacitinib Impurity 143 (CAS 1206875-41-3)
- Tofacitinib Impurity 13 (CAS 1812890-23-5)
- Tofacitinib Impurity 194 (CAS CATO-C4X-1079194)
- Tofacitinib Impurity N2 (CAS 1206825-36-6)
Recommended Standards
- 6-Chloro-N2-cyclopentyl-N4-isopropyl-1,3,5-triazine-2,4-diamine (CAS 84712-76-5)
- 3-((2-Chlorophenyl)thio)-N-cyclopropylpropanamide (CAS 1258685-80-1)
- 6-Chloro-N2-cyclohexyl-N4-ethyl-1,3,5-triazine-2,4-diamine (CAS 84712-77-6)
- 4-Chloro-1-(3-methoxypropanesulfonyl)piperidine (CAS 1344262-93-6)
- Fluvoxamine impurity 139 (CAS CATO-C4X-195139)
- Metaraminol Impurity 46 (CAS CATO-C4X-225246)
- Propranolol Impurity 39 (CAS CATO-C4X-151939)
- 3-Oxo-1,3-dihydroisobenzofuran-1-yl butyrate (CAS 108761-29-1)
- Ethyl (2R)-2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate (CAS 887375-49-7)
- 2-Amino-1-(2-((isopropyl(methyl)amino)methyl)piperidin-1-yl)ethanone (CAS 1353970-42-9)
- (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine (CAS 1123231-07-1)
- 13-(3,4,5-Trimethoxyphenyl)-1,8,10,12-tetraazatricyclo[7.4.0.0^{2,7}]trideca-2,4,6,8,11-pentaen-11-amine (CAS 306735-68-2)
- 4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol (CAS 577976-26-2)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com