Tofacitinib Impurity 143 CAS 1206875-41-3
| CAS No. | 1206875-41-3 |
| Molecular Formula | C15H22N2O2 |
| Molecular Weight | 262.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C15H22N2O2, Tofacitinib Impurity 143 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 262.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Tofacitinib Impurity 143 (CAS 1206875-41-3), a pharmacopoeial impurity reference standard (molecular formula C15H22N2O2, MW 262.35 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 143 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H22N2O2 |
| Molecular Weight | 262.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 74 (CAS CATO-C4X-107974)
- Tofacitinib Impurity 69 (CAS CATO-C4X-107969)
- Tofacitinib Impurity 166 (CAS 923036-28-6)
- Tofacitinib Impurity 11 (CAS 2227197-38-6)
- Tofacitinib Impurity 248 (CAS CATO-C4X-1079248)
- Tofacitinib Impurity 71 (CAS 134965-85-8)
- Tofacitinib Impurity 22 (CAS 2227199-28-0)
- Tofacitinib Impurity 111 (CAS 2183519-70-0)
Recommended Standards
- tert-butyl (4,6-dimethylisoindolin-5-yl)carbamate (CAS CATO-C3D-263260)
- Roxatidine Impurity 14 (CAS CATO-C4X-121314)
- tert-butyl (4,6-dimethylindolin-5-yl)carbamate (CAS CATO-C3D-263257)
- Quetiapine Impurity 47 (CAS 14258-43-6)
- Papaverine impurity 23 (CAS CATO-C4X-206723)
- Olodaterol Impurity 22 (CAS CATO-C4X-194322)
- Bromisoval Impurity 1 (CAS CATO-C4X-20631)
- 2-Methoxy-5-(2H-tetrazol-5-yl)aniline (CAS 383870-78-8)
- tert-Butyl 5-iodo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate (CAS 1198426-57-1)
- 1-{1-[(2-chloro-4-fluorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1h-1,3-benzodiazol-2-one (CAS 909682-49-1)
- Pyrrolidine-2,5-dicarboxylic acid (CAS 72000-65-8)
- 2-(3-(Difluoromethoxy)-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2092444-39-6)
- tert-Butyl (2-(2-formyl-6-(trifluoromethyl)pyridin-4-yl)ethyl)carbamate (CAS 1393553-45-1)
- Anxiety Peptide (CAS 95237-86-8)
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