Tofacitinib Impurity 74 CAS CATO-C4X-107974
| CAS No. | CATO-C4X-107974 |
| Molecular Formula | C13H18N4O2 |
| Molecular Weight | 262.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 74.
Tofacitinib Impurity 74 (CAS CATO-C4X-107974) is a certified pharmaceutical impurity reference standard with the molecular formula C13H18N4O2 and a molecular weight of 262.31 g/mol.
The molecular framework of Tofacitinib Impurity 74 (C13H18N4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tofacitinib Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18N4O2 |
| Molecular Weight | 262.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Tofacitinib Standards
- Tofacitinib Impurity 143 (CAS 1206875-41-3)
- Tofacitinib Impurity 69 (CAS CATO-C4X-107969)
- Tofacitinib Impurity 166 (CAS 923036-28-6)
- Tofacitinib Impurity 11 (CAS 2227197-38-6)
- Tofacitinib Impurity 248 (CAS CATO-C4X-1079248)
- Tofacitinib Impurity 71 (CAS 134965-85-8)
- Tofacitinib Impurity 22 (CAS 2227199-28-0)
- Tofacitinib Impurity 111 (CAS 2183519-70-0)
Recommended Standards
- 1-Amino-14-azido-3,6,9,12-tetraoxatetradecane 14-Amino-3,6,9,12-tetraoxatetradecanyl Azide 951671-92-4 Azido-PEG4-Amine O-(2-Aminoethyl)-O'-(2-azidoethyl)triethylene Glycol (CAS 951671-92-4)
- Ethambutol Impurity 8 (CAS 2792161-95-4)
- 35H0V3D0KK 6756-41-8 1-(4-Tolylazo)-2-naphthol 1-((4-Methylphenyl)azo)-2-naphthalenol CCRIS 4005 NSC 106296 UNII-35H0V3D0KK (CAS 6756-41-8)
- H-D-Phe-Pro-OH (CAS 51926-52-4)
- Ampicillin Impurity 100 (CAS CATO-C4X-1443100)
- Polymyxin Impurity 20 (CAS 343979-23-7)
- Lifitegrast Impurity 170 (CAS CATO-C4X-2409170)
- 2-(2-chloro-4-fluorophenoxymethyl)-8-methylimidazo[1,2-a]pyridine (CAS 871218-91-6)
- Palonosetron Impurity 49 (CAS CATO-C4X-110549)
- N-((5-(3-Methoxyphenyl)-1H-1,2,4-triazol-3-yl)methyl)aniline (CAS 1171933-50-8)
- 2-(4-(3-Chlorophenyl)piperazin-1-yl)-N-(2,4,5-trifluorophenyl)acetamide (CAS 303091-66-9)
- 5-Cyclopropyl-3-(difluoromethyl)-1H-pyrazole (CAS 1062296-03-0)
- N,N'-Bis(4-formylphenyl)-N,N'-diphenylbenzidine (CAS 137911-28-5)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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