Roflumilast Impurity 47 CAS CATO-C4X-108447
| CAS No. | CATO-C4X-108447 |
| Molecular Formula | C24H23F4NO6 |
| Molecular Weight | 497.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Roflumilast Impurity 47.
CATO supplies Roflumilast Impurity 47 (CAS CATO-C4X-108447), a pharmacopoeial impurity reference standard (molecular formula C24H23F4NO6, MW 497.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Roflumilast Impurity 47 (C24H23F4NO6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 497.44 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Roflumilast Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H23F4NO6 |
| Molecular Weight | 497.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Roflumilast Standards
- Roflumilast Impurity 46 (CAS CATO-C4X-108446)
- Roflumilast Impurity 59 (CAS CATO-C4X-193559)
- Roflumilast Impurity 48 (CAS CATO-C4X-108448)
- Roflumilast USP Related Compound E (CAS 3031785-18-6)
- Roflumilast Impurity 54 (CAS CATO-C4X-108454)
- Roflumilast Impurity 35 (CAS CATO-C4X-108435)
- Roflumilast-D4 N-Oxide (CAS 1794760-31-8)
- Roflumilast N-Oxide (CAS 292135-78-5)
Recommended Standards
- N-(2-Chloro-4,6-dimethylphenyl)-2-((5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476486-01-8)
- 3-Acetamido-6-acetyl-2-nitrophenyl 4-(benzyl(methyl)amino)-3,5-difluorobenzoate (CAS 1548406-01-4)
- Ethyl 2-(2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-4,5-diphenyl-1H-imidazol-1-yl)acetate (CAS 339277-35-9)
- Nicardipine Impurity 64 (CAS CATO-C4X-171064)
- Entacapone Impurity 10 (CAS CATO-C4X-162910)
- Epalrestat Impurity 62 (CAS 682775-70-8)
- Suvorexant Impurity 20 (CAS CATO-C4X-181220)
- 1171465-55-6 4-{[5-(4-Fluorophenyl)-4-methyl-1,1-dioxido-3-oxoisothiazol-2(3H)-yl]methyl}benzoic acid MFCD14282142 (CAS 1171465-55-6)
- 4-(3-((5-Chlorobenzo[b]thiophen-7-yl)amino)-1H-pyrazol-5-yl)phenol (CAS 1301750-00-4)
- 5-(Pyridazin-3-yl)nicotinonitrile (CAS 1346687-41-9)
- Serine lactone hydrochloride (CAS 2185-03-7)
- 1-(3-(Allyloxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 1558222-63-1)
- 1-(2-(4-Phenylpiperazin-1-yl)propyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1707734-88-0)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
Why CATO?
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