Ambroxol EP Impurity D CAS CATO-C4X-108545
| CAS No. | CATO-C4X-108545 |
| Molecular Formula | C13H18Br2N2O |
| Molecular Weight | 378.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ambroxol EP Impurity D is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ambroxol EP Impurity D (CAS CATO-C4X-108545), a pharmacopoeial impurity reference standard (molecular formula C13H18Br2N2O, MW 378.10 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ambroxol EP Impurity D (C13H18Br2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ambroxol EP Impurity D under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H18Br2N2O |
| Molecular Weight | 378.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol EP Impurity D (CAS 107814-37-9)
- Ambroxol Impurity 35 (CAS 36557-04-7)
- Ambroxol (CAS 18683-91-5)
- Ambroxol Impurity 103 (CAS 2499966-00-4)
- Ambroxol Impurity 11 (CAS CATO-C4X-108511)
- Ambroxol EP Impurity C (CAS 50910-53-7)
- Ambroxol Impurity 9 (CAS 1445719-53-8)
- Ambroxol D5DISCONTINUED, offer A575902 (CAS 1246818-80-3)
Recommended Standards
- 1,2-Bis(5-bromopyridin-2-yl)disulfane (CAS 872273-36-4)
- Sevoflurane Impurity 13 (CAS 194039-83-3)
- 2',7'-Dibromospiro[cyclopentane-1,9'-fluorene] (CAS 441771-49-9)
- (2R,3R,4S,5S)-2-(6-Hydroxy-9H-purin-9-yl)-5-(iodomethyl)tetrahydrofuran-3,4-diol (CAS 18945-36-3)
- Drotaverin Impurity 64 (CAS CATO-C4X-243564)
- Tildipirosin impurity 1 (CAS CATO-C4X-32761)
- Marbofloxacin EP Impurity E HCl (CAS 2249835-04-7 (free base))
- Tert-butyl ((2-chloro-3-(dimethoxymethyl)pyridin-4-yl)methyl)carbamate (CAS 1186310-71-3)
- N-methyl-2-(trifluoromethyl)-4-(((5-(trifluoromethyl)pyridin-2-yl)thio)methyl)aniline (CAS 860787-24-2)
- 4-((4-Bromo-1h-pyrazol-1-yl)methyl)benzohydrazide (CAS 512809-88-0)
- 6-(Propan-2-yl)-1h-indole-2-carboxylic acid (CAS 383132-73-8)
- 6-Chloro-2-cyclopropylquinoline-4-carboxylic Acid (CAS 854860-15-4)
- Pregnanetriol 3alpha-O-beta-D-Glucuronide (CAS 74915-85-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com