Ibrutinib Impurity 92 CAS CATO-C4X-106492
| CAS No. | CATO-C4X-106492 |
| Molecular Formula | C25H23ClN6O2 |
| Molecular Weight | 474.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Ibrutinib Impurity 92 (CAS CATO-C4X-106492), a pharmacopoeial impurity reference standard (molecular formula C25H23ClN6O2, MW 474.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Ibrutinib Impurity 92 (C25H23ClN6O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 474.94 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H23ClN6O2 |
| Molecular Weight | 474.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Ibrutinib Standards
- Ibrutinib Impurity 93 (CAS CATO-C4X-106493)
- Ibrutinib Impurity 13 (Mixture of Diastereomers) (CAS 1654820-87-7)
- Ibrutinib Impurity 3 (CAS 1288338-96-4)
- Ibrutinib Impurity 31 (CAS CATO-C4X-106431)
- Ibrutinib Impurity 137 (CAS CATO-C4X-1064137)
- Ibrutinib Impurity 160 (CAS CATO-C4X-1064160)
- Ibrutinib Impurity 169 (CAS CATO-C4X-1064169)
- Ibrutinib Impurity 44 (CAS 2031255-26-0)
Recommended Standards
- AP-768 (CAS 780763-95-3)
- alpha-[6-(Di-Boc-amino)-3-pyridyl]-5-chloro-1H-pyrrolo[2,3-b]pyridine-3-methanol (CAS 2040295-05-2)
- MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone (CAS 111682-13-4)
- 5-(4-((2-Chlorobenzyl)oxy)phenyl)-N'-(4-ethoxybenzylidene)-1H-pyrazole-3-carbohydrazide (CAS 634897-17-9)
- (S)-2-Amino-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid (CAS 878384-69-1)
- Formoterol Impurity N1 (CAS 43229-66-9)
- Benserazide Impurity 9 (CAS CATO-C4X-14279)
- 2-(o-Tolyl)pyrimidine (CAS 188527-65-3)
- Diphenyl(2,4,6-Trimethylbenzoyl)Phosphine Oxide (CAS 75980-60-8)
- 1-[(3-Methoxyphenyl)methyl]-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile (CAS 338955-37-6)
- n-((S)-1-(3-Chloroisoquinolin-6-yl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide (CAS 1509899-70-0)
- 2,2-Difluoro-2-(tetrahydrofuran-2-yl)acetic acid (CAS 170884-47-6)
- 2-(2,4-Dimethylphenoxy)-N-(5-methylisoxazol-3-yl)nicotinamide (CAS 1023435-45-1)
- Peptide Impurity 26 (CAS 1350456-66-4)
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