Tadalafil Impurity 183 CAS CATO-C4X-1087183
| CAS No. | CATO-C4X-1087183 |
| Molecular Formula | C23H22ClN3O4 |
| Molecular Weight | 439.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Tadalafil Impurity 183 (CAS CATO-C4X-1087183), a pharmacopoeial impurity reference standard (molecular formula C23H22ClN3O4, MW 439.89 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tadalafil Impurity 183 (C23H22ClN3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tadalafil Impurity 183 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22ClN3O4 |
| Molecular Weight | 439.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tadalafil Standards
- Tadalafil Impurity 158 (CAS 1863191-32-5)
- Tadalafil Impurity 48 (CAS CATO-C4X-108748)
- Tadalafil Impurity 157 (CAS CATO-C4X-1087157)
- Tadalafil Impurity 177 (CAS CATO-C4X-1087177)
- Tadalafil Impurity 54 (CAS 171596-32-0)
- Tadalafil Impurity 35 (CAS 2169996-11-4)
- Tadalafil Impurity 59 (CAS CATO-C4X-108759)
- Tadalafil Impurity 91 (CAS CATO-C4X-108791)
Recommended Standards
- 2-Chloro-4-fluoro-N-((4-(6-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-85-8)
- Losartan-d3 Carboxylic Acid (CAS 1189729-40-5)
- 2-Chloro-4-fluoro-N-((3-(6-methylbenzo[d]oxazol-2-yl)phenyl)carbamothioyl)benzamide (CAS 593238-50-7)
- 3-Amino-6-(2-chlorophenyl)-4-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 690642-63-8)
- Palbociclib Impurity 135 (CAS CATO-C4X-1125135)
- Paricalcitol Impurity 3 (CAS 1884139-61-0)
- Limaprost Impurity 16 (CAS CATO-C4X-214516)
- 3-(Benzyloxy)-3-oxo-2-phenylpropanoic acid (CAS 25774-02-1)
- di-tert-Butyl ((2S,2'S)-(thiocarbonylbis(azanediyl))bis(propane-1,2-diyl))dicarbamate (CAS 922495-32-7)
- 2-(Piperidin-4-yloxy)nicotinonitrile hydrochloride (CAS 1185310-20-6)
- 3,4-Di(furan-2-yl)-1-(pyridin-2-yl)-5,6,7,8-tetrahydroisoquinoline (CAS 692729-85-4)
- N-(2,2-dimethoxyethyl)-N’-methylethanediamide (CAS 58108-44-4)
- 2-Amino-3-(2-methoxy-5-nitrophenyl)propanoic acid (CAS 116366-23-5)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com