Diphenhydramine impurity 9 CAS CATO-C4X-14249
| CAS No. | CATO-C4X-14249 |
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Diphenhydramine impurity 9 (C17H20N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Diphenhydramine impurity 9 (CAS CATO-C4X-14249) is a certified pharmaceutical impurity reference standard with the molecular formula C17H20N2O2 and a molecular weight of 284.35 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Diphenhydramine Standards
- Diphenhydramine impurity 17 (CAS 22808-17-9)
- Diphenhydramine impurity 14 (CAS CATO-C4X-142414)
- Diphenhydramine N-Oxide (CAS 3922-74-5)
- Diphenhydramine impurity 18 (CAS 150556-79-9)
- Diphenhydramine EP Impurity B (CAS 19804-27-4)
- Diphenhydramine (CAS 58-73-1)
- Diphenhydramine EP Impurity A(Dimenhydrinate EP Impurity F) (CAS 17471-10-2)
- Diphenhydramine EP Impurity C (CAS 118-23-0)
Recommended Standards
- N-methyl-N-(2-(phenyl(o-tolyl)methoxy)ethyl)nitramide (CAS CATO-C4X-14248)
- Formoterol Impurity 104 (CAS CATO-C4X-1525104)
- N-Nitroso Diphenhydramine Impurity 11 (CAS CATO-C4X-142411)
- N-Nitroso Formoterol Impurity 108 (CAS CATO-C4X-1525108)
- Thioctic acid impurity 61 (CAS 26825-92-3)
- Cabazitaxel Impurity 14 (CAS CATO-C4X-111514)
- Sorbitol impurity 4 (CAS 86334-50-1)
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- (2S)-pyrrolidin-2-ylmethanesulfonamide (CAS 1821827-86-4)
- (1-(4-(Trifluoromethyl)phenyl)cyclohexyl)methanamine (CAS 944348-11-2)
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- 2-Cyano-4-(1,3-dioxolan-2-yl)benzophenone (CAS 898759-92-7)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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