Amlodipine Impurity 78 CAS CATO-C4X-109578
| CAS No. | CATO-C4X-109578 |
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amlodipine Impurity 78 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Amlodipine Impurity 78 (CAS CATO-C4X-109578, C20H22ClNO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Amlodipine Impurity 78 (C20H22ClNO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Amlodipine Impurity 78 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity N1 (CAS 194472-27-0)
- Amlodipine Impurity 30 (CAS 496024-43-2)
- Amlodipine Impurity 60 (CAS 949155-13-9)
- Amlodipine Impurity 83 (CAS CATO-C4X-109583)
- Amlodipine Impurity 76 (CAS CATO-C4X-109576)
- Amlodipine Impurity N20 (CAS 2170104-02-4)
- Amlodipine Impurity 77 (CAS 2802443-91-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- Avanafil Impurity 5 (CAS 372117-54-9)
- 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid 9H-fluoren-9-ylmethyl ester 916420-25-2 9H-fluoren-9-ylmethyl 4-chloranyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate A844013 (CAS 916420-25-2)
- Avanafil Impurity 89 (CAS 2250243-36-6)
- VER 49009 (CAS 558640-51-0)
- Ketoprofen Impurity 93 (CAS 2733641-85-3)
- Landiolol Impurity 72 (CAS CATO-C4X-262172)
- Ozenoxacin Impurity 77 (CAS CATO-C4X-279677)
- 1-(2-Chloropyridin-3-yl)-2,2,2-trifluoroethanol (CAS 1713713-74-6)
- Ceftolozane impurity 7 (CAS 1956303-45-9)
- Ethyl 4-(Trifluoromethyl)thiazole-2-carboxylate (CAS 79247-86-2)
- 7-Nitrophthalazin-1(2H)-one (CAS 89898-94-2)
- 5-(4-Benzyl-1-piperazinyl)-2-(methylsulfonyl)-phenylamine (CAS 1219972-42-5)
- 4-((3-Acetylphenyl)amino)-4-oxo-2-(piperidin-1-yl)butanoic acid (CAS 899991-96-9)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com