Amlodipine Impurity N1 CAS 194472-27-0
| CAS No. | 194472-27-0 |
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Amlodipine Impurity N1 (C20H22ClNO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 391.85 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Amlodipine Impurity N1 (CAS 194472-27-0), a pharmacopoeial impurity reference standard (molecular formula C20H22ClNO5, MW 391.85 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amlodipine Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity 30 (CAS 496024-43-2)
- Amlodipine Impurity 60 (CAS 949155-13-9)
- Amlodipine Impurity 78 (CAS CATO-C4X-109578)
- Amlodipine Impurity 83 (CAS CATO-C4X-109583)
- Amlodipine Impurity 76 (CAS CATO-C4X-109576)
- Amlodipine Impurity N20 (CAS 2170104-02-4)
- Amlodipine Impurity 77 (CAS 2802443-91-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- 2-(4-Chlorophenoxy)-N-(4-(dimethylamino)-2-morpholinopyrimidin-5-yl)acetamide (CAS 1797622-75-3)
- 2-(4-Chlorobenzyl)-5-methyl-4-(4-phenoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 860784-90-3)
- (2S,4S)-1-(tert-butoxycarbonyl)-4-((4-chloronaphthalen-1-yl)oxy)pyrrolidine-2-carboxylic acid (CAS 1354487-47-0)
- 3-((4-Chlorophenyl)amino)-2-(3,4-dimethoxyphenyl)-1H-inden-1-one (CAS 946386-82-9)
- Milnacipran impurity 29 (CAS 1353644-50-4)
- Dotinurad Impurity 77 (CAS 35458-33-4)
- Rasagiline Impurity 3 HCl (CAS CATO-C4X-19133)
- (S)-5-(difluoromethyl)-2-methyl-3-((3-methylpiperazin-1-yl)methyl)aniline (CAS 2172942-36-6)
- 2-((3,4-Dichlorophenyl)amino)-2-phenylacetonitrile (CAS 71144-20-2)
- 4-(4-Benzylphenoxy)-3-(trifluoromethyl)aniline (CAS 946740-90-5)
- 2-(Piperidin-1-ylmethyl)pyridin-3-ol (CAS 2168-16-3)
- 6-Bromo-4,4'-dimethyl-2,2'-bipyridyl (CAS 850413-36-4)
- Letermovir Impurity 1(Racemate) (CAS CATO-CP155162)
- Eosinophilotactic Peptide (CAS 61756-28-3)
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