Amlodipine Impurity 30 CAS 496024-43-2
| CAS No. | 496024-43-2 |
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Amlodipine Impurity 30 (CAS 496024-43-2, C20H22ClNO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Amlodipine Impurity 30 (C20H22ClNO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 391.85 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H22ClNO5 |
| Molecular Weight | 391.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity N1 (CAS 194472-27-0)
- Amlodipine Impurity 60 (CAS 949155-13-9)
- Amlodipine Impurity 78 (CAS CATO-C4X-109578)
- Amlodipine Impurity 83 (CAS CATO-C4X-109583)
- Amlodipine Impurity 76 (CAS CATO-C4X-109576)
- Amlodipine Impurity N20 (CAS 2170104-02-4)
- Amlodipine Impurity 77 (CAS 2802443-91-8)
- Amlodipine Impurity 38 (CAS 113994-37-9)
Recommended Standards
- 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid 9H-fluoren-9-ylmethyl ester 916420-25-2 9H-fluoren-9-ylmethyl 4-chloranyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate A844013 (CAS 916420-25-2)
- VER 49009 (CAS 558640-51-0)
- N-(4-((3-(2-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)amino)phenyl)acetamide (CAS 890635-18-4)
- N-(3-Chloro-4-fluorophenyl)-2-((4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618415-13-7)
- Ribociclib Impurity 13 (CAS 158328-38-2)
- Lenvatinib Impurity 102 (CAS 15568-85-1)
- Tadalafil Impurity 29 (CAS CATO-C4X-1087129)
- rel-(1R,2R)-2-(4-Methylpyrimidin-2-yl)cyclopropane-1-carboxylic acid (CAS 2839649-20-4)
- 4-(Thiophen-2-ylmethyl)piperidin-4-ol (CAS 1521019-01-1)
- 8-Nitro-1,2,3,4-tetrahydrodibenzo[b,d]furan (CAS 13680-12-1)
- (2-(7-Chlorobenzo[d][1,3]dioxol-5-yl)cyclopropyl)methanamine (CAS 1283906-43-3)
- 2-cyclopentyl-1-(4-phenoxyphenyl)ethan-1-one (CAS 1183760-48-6)
- 4-Hydroxypiperidine-4-carboxylic Acid (CAS 50289-06-0)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
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