Agomelatine impurity 40 CAS CATO-C4X-110840
| CAS No. | CATO-C4X-110840 |
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Agomelatine impurity 40 (C11H12O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Agomelatine impurity 40 (CAS CATO-C4X-110840, C11H12O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Agomelatine impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Agomelatine Standards
- Agomelatine Impurity 65 (CAS 579465-07-9)
- Agomelatine Impurity 15 (CAS 138113-08-3)
- Agomelatine Impurity 63 (CAS 158365-53-8)
- Agomelatine Impurity N15 (CAS 1607465-48-4)
- Agomelatine Impurity 23 (CAS 178676-65-8)
- Agomelatine Impurity 36 (CAS 127299-26-7)
- Agomelatine Impurity 41 (CAS 2243666-95-5)
- Agomelatine Impurity 49 (CAS CATO-C4X-110849)
Recommended Standards
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- Zolmitriptan Impurity 41 (CAS CATO-C4X-135141)
- Esomeprazole Impurity 108 (CAS 74409-42-0)
- Carbetocin Impurity 7 (CAS CATO-C4X-19117)
- Tigecycline Impurity 33 (CAS CATO-C4X-186033)
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