Gefitinib Impurity 23 HCl CAS CATO-C4X-111723
| CAS No. | CATO-C4X-111723 |
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Gefitinib Impurity 23 HCl (CAS CATO-C4X-111723), a pharmacopoeial impurity reference standard (molecular formula C16H13ClFN3O2HCl, MW 370.20 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Gefitinib Impurity 23 HCl (C16H13ClFN3O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefitinib Impurity 23 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13ClFN3O2 HCl |
| Molecular Weight | 370.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Gefitinib Standards
- Gefitinib Impurity 48 (CAS 1006378-06-8)
- Gefitinib-d3 (CAS 1173976-40-3)
- Gefitinib-d8 (CAS 1228664-49-0)
- Gefitinib Impurity 28 (CAS 1379208-77-1)
- Gefitinib Impurity 1 (CAS 1502829-45-9)
- Gefitinib Impurity 19 (CAS 153437-78-6)
- Gefitinib Impurity 58 DiHCl (CAS 1561173-24-7（1*HCl Salt)）)
- Gefitinib Impurity 10 (CAS 1603814-04-5)
Recommended Standards
- Cladribine EP Impurity G (CAS 99-75-2)
- Vonoprazan Impurity 268 (CAS CATO-C4X-1020268)
- Netupitant Impurity 46 (CAS CATO-C4X-122346)
- Pyridine-2,6-dicarbohydrazide (CAS 5112-36-7)
- 4-Bromo-2-(3-methyl-1H-pyrazol-1-yl)pyridine (CAS 1159814-76-2)
- 2-Cyanoethyl (E)-3-(allyloxy)acrylate (CAS CATO-C4X-2880248)
- 2-((5-Chloro-2-((4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide (CAS 1042432-58-5)
- Piperazin-1-yl(piperidin-2-yl)methanone (CAS 1218014-10-8)
- But-3-en-1-yl 2-hydroxypropanoate (CAS 823783-05-7)
- Allo-Thr7-Tirzepatide (CAS CATO-CPTD788933)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com