Gefitinib Impurity 74 CAS CATO-C4X-111774
| CAS No. | CATO-C4X-111774 |
| Molecular Formula | C13H16O5 |
| Molecular Weight | 252.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 252.26 g/mol gives Gefitinib Impurity 74 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Gefitinib Impurity 74 (CAS CATO-C4X-111774) is a certified pharmaceutical impurity reference standard with the molecular formula C13H16O5 and a molecular weight of 252.26 g/mol.
The molecular framework of Gefitinib Impurity 74 (C13H16O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Gefitinib Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16O5 |
| Molecular Weight | 252.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Gefitinib Standards
- Gefitinib Impurity 42 (CAS 230955-75-6)
- Gefitinib Impurity 86 (CAS CATO-C4X-111786)
- Gefitinib Impurity 40 (CAS 179688-53-0)
- Gefitinib Impurity 25 (CAS 385784-68-9)
- Gefitinib Impurity 79 (CAS CATO-C4X-111779)
- Gefitinib impurity 71 (CAS CATO-C4X-111771)
- Gefitinib Impurity 55 (CAS 675126-28-0)
- Gefitinib Impurity 57 (CAS 861453-11-4)
Recommended Standards
- (4-hydroxy-3-methyl-2-benzofuranyl)phenylMethanone 99246-64-7 (CAS 99246-64-7)
- Repaglinide EP Impurity B (CAS 99469-99-5)
- 3-Hydroxy-2,8-dimethyl-1,4-phenanthraquinone 65907-77-9 (CAS 65907-77-9)
- Olopatadine lmpurity 57 (CAS CATO-C4X-171857)
- Ibuprofen Impurity 52 (CAS 67381-50-4)
- Perospirone Impurity 2 (CAS 7506-66-3)
- Telmisartan Impurity 28 (CAS 152628-03-0)
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- 1-(3-Bromoprop-1-yn-1-yl)naphthalene (CAS 352035-98-4)
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