Sorafenib impurity 66 CAS CATO-C4X-112466
| CAS No. | CATO-C4X-112466 |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sorafenib impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sorafenib impurity 66 (CAS CATO-C4X-112466, C8H9NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sorafenib impurity 66 (C8H9NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 53 (CAS 611226-36-9)
- Sorafenib Impurity 64 (CAS 99586-65-9)
- Sorafenib Impurity 48 (CAS 5470-22-4)
- Sorafenib Impurity 26 (CAS 1693-39-6)
- Sorafenib Impurity 28 (CAS CATO-C4X-112428)
- Sorafenib Impurity 50 (CAS 1065074-98-7)
- Sorafenib Impurity 24 (CAS 6144-78-1)
- Sorafenib Impurity 67 (CAS 131418-11-6)
Recommended Standards
- Milrinone Impurity 24 (CAS CATO-C4X-109124)
- Paracetamol EP Impurity A (CAS 614-80-2)
- Etoricoxib impurity 64 (CAS 65719-09-7)
- Paracetamol EP Impurity G (CAS 34523-34-7)
- Vortioxetine Impurity 153 (CAS CATO-C4X-1056153)
- Ozagrel Impurity 12 (CAS 530145-11-0)
- Sunitinib Impurity N1 (CAS 2377533-92-9)
- 2-(4-Methoxyphenyl)quinoline-3,4-dicarboxylic acid (CAS 88344-64-3)
- 2-({1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-imidazol-2-yl}sulfanyl)-1-(4-chlorophenyl)ethan-1-one (CAS 339276-71-0)
- 2-Methyl-4-(trimethylsilyl)quinoline (CAS 124393-06-2)
- Ethanethioic Acid S-[3-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]propyl] Ester (CAS 1088-37-5)
- 2-Methoxy-4-methylbenzophenone (CAS 28137-36-2)
- 2-(Ethylthio)-N-methylethan-1-amine (CAS 847975-59-1)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
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