Palbociclib impurity 162 CAS CATO-C4X-1125162
| CAS No. | CATO-C4X-1125162 |
| Molecular Formula | C22H26ClN7O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Palbociclib impurity 162 (CAS CATO-C4X-1125162, C22H26ClN7OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Palbociclib impurity 162 (C22H26ClN7OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 476.41 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H26ClN7O HCl |
| Molecular Weight | 476.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib Impurity 96 (CAS 1013916-37-4)
- Palbociclib Impurity 25 (CAS 1016636-76-2)
- Palbociclib Impurity 6 (CAS 1023594-49-1)
- Palbociclib Impurity 26 (CAS 1023594-50-4)
- Palbociclib Impurity 2 (CAS 1072-97-5)
- Palbociclib Impurity 32 (CAS 1082876-26-3)
- Palbociclib Impurity 204 (CAS 119285-06-2（free base）)
- Palbociclib Impurity 208 (CAS 120613-50-5)
Recommended Standards
- Gadobutrol impurity 62 (CAS CATO-C4X-2120162)
- Sacubitril impurity 42 (CAS CATO-C4X-280942)
- Erlotinib Impurity 30 (CAS CATO-C4X-106930)
- 5-(Dimethoxymethyl)-1-methyl-1H-pyrazole (CAS 1269291-90-8)
- 2-[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]acetonitrile (CAS 852933-96-1)
- Physostigmine Hemisulfate (CAS 64-47-1)
- (2-Methoxyphenyl)(pyridin-3-yl)methanone (CAS 55030-30-3)
- Benzyl ((1-(2-aminoacetyl)piperidin-2-yl)methyl)(cyclopropyl)carbamate (CAS 1353962-39-6)
- 6-Bromo-2-chloro-8-methylquinoline-3-carboxylic acid (CAS 1429903-89-8)
- Semaglutide238 (CAS CATO-C4X-2226238)
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