Sildenafil Impurity 22 HCl CAS CATO-C4X-112822
| CAS No. | CATO-C4X-112822 |
| Molecular Formula | C20H28N6O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Sildenafil Impurity 22 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Sildenafil Impurity 22 HCl (CAS CATO-C4X-112822, C20H28N6O4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sildenafil Impurity 22 HCl (C20H28N6O4SHCl) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H28N6O4S HCl |
| Molecular Weight | 485.00 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Sildenafil Standards
- Sildenafil Impurity N6 (CAS 1004455-71-3)
- Sildenafil Impurity 258 (CAS 1007310-62-4)
- Sildenafil Impurity 256 (CAS 1027192-9-2)
- Sildenafil Impurity 5 (CAS 1058653-74-9)
- Sildenafil Impurity 29 (CAS 1093065-15-6)
- Sildenafil EP Impurity B (CAS 1094598-75-0)
- Sildenafil-D3 (CAS 1126745-90-1)
- Sildenafil Impurity 62 (CAS 116833-23-9)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com