Sildenafil Impurity 253 CAS CATO-C4X-1128253
| CAS No. | CATO-C4X-1128253 |
| Molecular Formula | C8H13N3O3 |
| Molecular Weight | 199.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sildenafil Impurity 253 (CAS CATO-C4X-1128253, C8H13N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H13N3O3, Sildenafil Impurity 253 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 199.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sildenafil Impurity 253 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H13N3O3 |
| Molecular Weight | 199.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Sildenafil Standards
- Sildenafil Impurity 45 (CAS 62871-12-9)
- Sildenafil Impurity 99 (CAS CATO-C4X-112899)
- Sildenafil Impurity 21 (CAS 268204-00-8)
- Sildenafil Impurity 54 (CAS 133261-07-1)
- Sildenafil Impurity 30 (CAS 59259-90-4)
- Sildenafil Impurity 56 (CAS CATO-C4X-112856)
- Sildenafil Impurity 274 (CAS 1358966-40-1)
- Sildenafil RC 39 (CAS 1346605-36-4)
Recommended Standards
- 2-(Pyridin-2-yl)benzoic acid (CAS 13764-20-0)
- Ilaprazole Impurity 36 (CAS 1018229-53-2)
- (1-oxido-2-pyridinyl)(phenyl)methanone (CAS CATO-C3D-262535)
- Picosulfate Impurity 10 (CAS 33077-70-2)
- Vericiguat Impurity N dihydrochloride (CAS 1426309-48-9)
- Lenvatinib Impurity 153 (CAS CATO-C4X-1140153)
- Dabrafenib Impurity 22 (CAS CATO-C4X-303322)
- Ethyl 4-cyano-5-(ethylamino)-3-iodothiophene-2-carboxylate (CAS 1956382-78-7)
- 2-Bromo-1,5-difluoro-3-nitrobenzene (CAS 877161-74-5)
- (S)-2-[Bis(3,5-dimethylphenyl)methoxymethyl]pyrrolidine hydrochloride (CAS 948595-07-1)
- 351062-23-2 3-Amino-3-[1-(4-nitrophenyl)-1H-pyrrol-2-yl]propanoic acid MFCD02140235 (CAS 351062-23-2)
- 3-Fluorophenethylzinc bromide (CAS 1142275-36-2)
- Atrasentan Impurity 103 (CAS 1059052-06-0)
- Semaglutide impurity 65 (CAS CATO-C4X-222665)
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