Dabrafenib Impurity 22 CAS CATO-C4X-303322
| CAS No. | CATO-C4X-303322 |
| Molecular Formula | C13H8F2I2N2O |
| Molecular Weight | 500.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Dabrafenib Impurity 22 (CAS CATO-C4X-303322, C13H8F2I2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dabrafenib Impurity 22 (C13H8F2I2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H8F2I2N2O |
| Molecular Weight | 500.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Dabrafenib Standards
- Dabrafenib Impurity 32 (CAS CATO-C4X-303332)
- Dabrafenib Impurity 17 (CAS 1613724-51-8)
- Dabrafenib Impurity N1 (CAS 1195765-47-9)
- Dabrafenib Impurity 2 (CAS CATO-C4X-30332)
- Dabrafenib Impurity 1 (CAS 2017554-98-0)
- Dabrafenib Impurity 13 (CAS CATO-C4X-303313)
- Dabrafenib Impurity 40 (CAS CATO-C4X-303340)
- Dabrafenib (CAS 1195765-45-7)
Recommended Standards
- 2-((4-(4-Chlorophenyl)-3-cyano-6-(4-methoxyphenyl)pyridin-2-yl)thio)-N-phenylpropanamide (CAS 444157-50-0)
- N-(3-chloro-4-methoxyphenyl)-2-((3-ethyl-4-oxo-7-(p-tolyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide (CAS 1040632-87-8)
- Z-Ala-Pro-Phe-chloromethylketone (CAS 217658-18-9)
- N-(5-Chloro-2-methoxyphenyl)-2-{[3-ethyl-7-(4-methylphenyl)-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide (CAS 1040651-81-7)
- Bromhexine Impurity 31 (CAS CATO-C4X-106031)
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- 2-(Pyrrolidin-3-yloxy)pyridine-4-carbonitrile hydrochloride (CAS 1420807-16-4)
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- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
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