Olaparib Impurity 21 CAS CATO-C4X-1135121
| CAS No. | CATO-C4X-1135121 |
| Molecular Formula | C25H25FN4O3 |
| Molecular Weight | 448.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 448.49 g/mol gives Olaparib Impurity 21 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Olaparib Impurity 21 (CAS CATO-C4X-1135121), a pharmacopoeial impurity reference standard (molecular formula C25H25FN4O3, MW 448.49 g/mol) used for the identification and quantification of trace impurities in APIs.
Olaparib Impurity 21 (C25H25FN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H25FN4O3 |
| Molecular Weight | 448.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 120 (CAS CATO-C4X-1135120)
- Olaparib Impurity 151 (CAS CATO-C4X-1135151)
- Olaparib Impurity 163 (CAS 1460272-52-9)
- Olaparib Impurity 9 (CAS CATO-C4X-11359)
- Olaparib Impurity 10 (CAS CATO-C4X-113510)
- Olaparib Impurity 7 (CAS CATO-C4X-11357)
- Olaparib Impurity 160 (CAS CATO-C4X-1135160)
- Olaparib Impurity 118 (CAS CATO-C4X-1135118)
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