Lenvatinib Impurity 67 CAS 2380197-90-8
| CAS No. | 2380197-90-8 |
| Molecular Formula | C28H22ClN5O5 |
| Molecular Weight | 543.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Lenvatinib Impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Lenvatinib Impurity 67 (CAS 2380197-90-8, C28H22ClN5O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H22ClN5O5, Lenvatinib Impurity 67 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 543.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H22ClN5O5 |
| Molecular Weight | 543.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Lenvatinib Standards
- Lenvatinib Impurity 58 (CAS CATO-C4X-114058)
- Lenvatinib Impurity 123 (CAS CATO-C4X-1140123)
- Lenvatinib Impurity 125 (CAS CATO-C4X-1140125)
- Lenvatinib Impurity 126 (CAS CATO-C4X-1140126)
- Lenvatinib Impurity 181 (CAS CATO-C4X-1140181)
- Lenvatinib Impurity 182 (CAS CATO-C4X-1140182)
- Lenvatinib Impurity 88 (CAS CATO-C4X-114088)
- Lenvatinib Impurity 145 (CAS CATO-C4X-1140145)
Recommended Standards
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- Sofosbuvir Impurity 71 (CAS CATO-C4X-105271)
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- 3-Chloro-5-((difluoromethyl)sulfonyl)benzoic acid (CAS 2592405-50-8)
- (2-Chloro-6-fluorophenyl)(3-hydroxypiperidin-1-yl)methanone (CAS 1154909-89-3)
- 2-Chloro-4,5-difluoro-3-(1,3-dioxan-2-yl)-propiophenone (CAS 898757-29-4)
- Ethylene glycol dibenzyl ether (CAS 622-22-0)
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