Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) CAS 2892260-32-9

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.2892260-32-9
Molecular FormulaC6H6F3N5O
Molecular Weight221.14 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) CAS 2892260-32-9 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 221.14 g/mol gives Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9), a pharmacopoeial impurity reference standard (molecular formula C6H6F3N5O, MW 221.14 g/mol) used for the identification and quantification of trace impurities in APIs.

Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (C6H6F3N5O) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H6F3N5O
Molecular Weight221.14 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity>95%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2004
Halogen ContentF-containing
Nitrogen Atoms5

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