Methotrexate Impurity 45 CAS CATO-C4X-115445
| CAS No. | CATO-C4X-115445 |
| Molecular Formula | C32H42N8O15 |
| Molecular Weight | 778.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Methotrexate Impurity 45 (CAS CATO-C4X-115445), a pharmacopoeial impurity reference standard (molecular formula C32H42N8O15, MW 778.72 g/mol) used for the identification and quantification of trace impurities in APIs.
Methotrexate Impurity 45 (C32H42N8O15) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Methotrexate Impurity 45 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C32H42N8O15 |
| Molecular Weight | 778.72 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
Related Methotrexate Standards
- Methotrexate Tetraglutamate (CAS 73610-81-8)
- Methotrexate Triglutamate (CAS 41600-14-0)
- Methotrexate EP Impurity G (CAS 2519848-42-9)
- Methotrexate Impurity 82 (CAS CATO-C4X-115482)
- Methotrexate Diglutamate (CAS 41600-13-9)
- Methotrexate Impurity 72 (CAS CATO-C4X-115472)
- Methotrexate Impurity 73 (CAS CATO-C4X-115473)
- Methotrexate impurity 57 (CAS CATO-C4X-115457)
Recommended Standards
- Methyltetrazine-PEG8-PFP ester (CAS 2353409-49-9)
- 4,4',4'',4'''-(1,3,6,8-Pyrenetetrayltetra-2,1-ethynediyl)tetrakis benzoic acid (CAS 1569900-71-5)
- Etoposide EP Impurity G (CAS CATO-C4X-20247)
- (2R)-3,6-Dihydro-6-oxo-2-(2-phenylethyl)-2-propyl-5-[(1R)-1-[3-[[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]amino]phenyl]propyl]-2H-pyran-4-yl |A-D-Glucopyranosiduronic Acid 947408-14-2 Tipranavir Glucuronide Tipranavir |A-D-Glucuronide (CAS 947408-14-2)
- Terbinafine lmpurity 36 (CAS CATO-C4X-133836)
- Vonoprazan Impurity 296 (CAS CATO-C4X-1020296)
- Ensifentrine impurity 34 (CAS CATO-C4X-335334)
- 2-(3-Amino-1h-pyrazol-1-yl)-N-ethylpropanamide (CAS 1179076-83-5)
- (1R,2R)-1-Cyano-2-(difluoromethyl)cyclopropanecarboxylic acid (CAS 2750509-75-0)
- (S)-2-(2'-(bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphanyl)-[1,1'-biphenyl]-2-yl)-4-phenyl-4,5-dihydrooxazole (CAS 1198791-48-8)
- Ethyl 4-(4H-1,2,4-triazol-4-yl)benzoate (CAS 167626-25-7)
- 3-Cyclopropoxy-2-sulfamoylbenzoic acid (CAS 1243346-10-2)
- Propyl 3-methylbutanethioate (CAS 2432-58-8)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com