Methotrexate Tetraglutamate CAS 73610-81-8
| CAS No. | 73610-81-8 |
| Molecular Formula | C35H43N11O14 |
| Molecular Weight | 841.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methotrexate Tetraglutamate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Methotrexate Tetraglutamate (CAS 73610-81-8), a certified reference material (molecular formula C35H43N11O14, MW 841.78 g/mol) for analytical method development and quality control.
Structurally, Methotrexate Tetraglutamate (C35H43N11O14) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 841.78 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C35H43N11O14 |
| Molecular Weight | 841.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 11 |
Related Methotrexate Standards
- Methotrexate Impurity 45 (CAS CATO-C4X-115445)
- Methotrexate Triglutamate (CAS 41600-14-0)
- Methotrexate EP Impurity G (CAS 2519848-42-9)
- Methotrexate Impurity 82 (CAS CATO-C4X-115482)
- Methotrexate Diglutamate (CAS 41600-13-9)
- Methotrexate Impurity 72 (CAS CATO-C4X-115472)
- Methotrexate Impurity 73 (CAS CATO-C4X-115473)
- Methotrexate impurity 57 (CAS CATO-C4X-115457)
Recommended Standards
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- Ethyl 7-Chloroquinoline-3-carboxylate (CAS 133455-49-9)
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- (S,R,S)-AHPC-CO-C2-NH2 HCl (CAS 2241643-69-4)
- N-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 330792-75-1)
- Pitolisant impurity 33 (CAS CATO-C4X-252033)
- 6-Ethoxynaphthalene-2-thiol (CAS 1379331-64-2)
- 1-((4-Methyl-1,2,5-oxadiazol-3-yl)methyl)-1h-pyrazol-3-amine (CAS 1340141-79-8)
- Dexchlorpheniramine EP Impurity B Maleate (CAS 23095-76-3)
- (Tyr9)-Cholecystokinin Octapeptide (sulfated) (H-9770.0005) (CAS 96607-61-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com