N-Nitroso Methotrexate EP Impurity B CAS CATO-C4X-115449
| CAS No. | CATO-C4X-115449 |
| Molecular Formula | C19H20N9O6 |
| Molecular Weight | 470.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H20N9O6, N-Nitroso Methotrexate EP Impurity B contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 470.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
N-Nitroso Methotrexate EP Impurity B (CAS CATO-C4X-115449) is a certified pharmaceutical impurity reference standard with the molecular formula C19H20N9O6 and a molecular weight of 470.42 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), N-Nitroso Methotrexate EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H20N9O6 |
| Molecular Weight | 470.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 9 |
Related N Standards
- N-Nitroso Folic acid EP Impurity C (CAS 29291-35-8)
- N10-Nitroso Folic Acid (CAS 26360-21-4)
- N-nitroso-folic acid (CAS CATO-C4X-139569)
- N-Nitroso Vilazodone (CAS CATO-C4X-135513)
- N1-Nitroso Tirofiban (CAS CATO-C4X-1254121)
- N-Nitroso Norverapamil (CAS CATO-C4X-177842)
- N-Nitroso 2-Deamino-2-Hydroxyfolic acid (CAS CATO-C3D-262126)
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Recommended Standards
- 71A048XW8V 511-89-7 Plumieride Spiro(cyclopenta(c)pyran-7(1H),2'(5'H)-furan)-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-4a,7a-dihydro-4-(1-hydroxyethyl)-5'-oxo-, methyl ester, (1S-(1alpha,4aalpha,7alpha(R*),7aalpha))- UNII-71A048XW8V (CAS 511-89-7)
- Moluccanin diacetate (CAS 121700-27-4)
- [5-(4-Fluorophenoxy)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 3-(trifluoromethyl)benzoate (CAS 956262-56-9)
- (S)-2,2',2'',2'''-((3-(4-(2-(Aminooxy)acetamido)phenyl)propane-1,2-diyl)bis(azanetriyl))tetraacetic acid (CAS 1217704-71-6)
- Epalrestat impurity 48 (CAS CATO-C4X-223648)
- Diphenoxylate Impurity 4 (CAS 84255-02-7)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Methyl 2-azabicyclo[4.1.0]Heptane-7-carboxylate (CAS 1368380-12-4)
- 3-(4-Isopropylpiperazin-1-yl)indolizine-6-carboxylic acid (CAS 1422066-99-6)
- 94641-55-1 Butanedioic acid-1,2-13C2 Succinic acid-1,2-13C2 (CAS 94641-55-1)
- (Z)-2-(4-Hydroxybenzylidene)benzo[4,5]imidazo[2,1-b]thiazol-3(2H)-one (CAS 155099-32-4)
- 1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylic acid (CAS 449210-08-6)
- 6-(Difluoromethyl)-5-fluoro-3-(trifluoromethyl)picolinonitrile (CAS 1804712-89-7)
- Peptide Impurity 82 (CAS 10491-78-8)
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