N-Nitroso Minocycline EP Impurity C CAS 28698-93-3
| CAS No. | 28698-93-3 |
| Molecular Formula | C22H24N4O8 |
| Molecular Weight | 472.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-Nitroso Minocycline EP Impurity C is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-Nitroso Minocycline EP Impurity C (CAS 28698-93-3) is a certified pharmaceutical impurity reference standard with the molecular formula C22H24N4O8 and a molecular weight of 472.45 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, N-Nitroso Minocycline EP Impurity C is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 472.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24N4O8 |
| Molecular Weight | 472.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 4 |
Related N Standards
- N-Nitroso Minocycline impurity 80 (CAS CATO-C4X-169980)
- N1-Nitroso Mitoxantrone (CAS CATO-C4X-103412)
- N-Nitroso Mitoxantrone Impurity 8 (CAS CATO-C4X-10348)
- N-Nitroso 2-Deamino-2-Hydroxyfolic acid (CAS CATO-C3D-262126)
- N-Nitroso Vilazodone (CAS CATO-C4X-135513)
- N-Nitroso Methotrexate EP Impurity B (CAS CATO-C4X-115449)
- N-Nitroso Folic acid EP Impurity C (CAS 29291-35-8)
- N10-Nitroso Folic Acid (CAS 26360-21-4)
Recommended Standards
- Folic acid impurity 58 (CAS CATO-C4X-139558)
- Minocycline Impurity 33 (CAS CATO-C4X-169933)
- Folic Acid Impurity 35 (CAS 2311-81-1)
- Minocycline Impurity 57 (CAS CATO-C4X-169957)
- Drotaverin Impurity 72 (CAS CATO-C4X-243572)
- Isosorbide Dinitrate Impurity 8 (CAS 39698-15-2)
- Levocetirizine Impurity 68 (CAS CATO-C4X-108368)
- 1-(4-Fluorophenyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1206801-35-5)
- 5-(chloromethyl)-1-methyl-1H-1,2,3-benzotriazole (CAS 149440-48-2)
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