Fosaprepitant Impurity 42 CAS CATO-C4X-116842
| CAS No. | CATO-C4X-116842 |
| Molecular Formula | C34H31F7NO5P |
| Molecular Weight | 697.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Fosaprepitant Impurity 42 (CAS CATO-C4X-116842, C34H31F7NO5P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fosaprepitant Impurity 42 (C34H31F7NO5P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C34H31F7NO5P |
| Molecular Weight | 697.58 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 44 (CAS CATO-C4X-116844)
- Fosaprepitant Impurity 45 (CAS CATO-C4X-116845)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Fosaprepitant Impurity 22 (CAS CATO-C4X-116822)
- Fosaprepitant Impurity 34 (CAS CATO-C4X-116834)
- Fosaprepitant Impurity 52 (CAS CATO-C4X-116852)
- Fosaprepitant impurity 10 (CAS CATO-C4X-116810)
- Fosaprepitant Impurity 35 (CAS CATO-C4X-116835)
Recommended Standards
- Platinum, (1,2-cyclohexanediamine-N,N')bis(D-gluconato-O1-, [SP-4-2-(1S-trans)] (CAS 82310-64-3)
- Tallimustine (CAS 115308-98-0)
- 5,8-Dibromo-2,3-bis(4-(octyloxy)phenyl)pyrido[3,4-b]pyrazine (CAS 1428539-93-8)
- Tris(2,3-Dibromopropyl)Phosphate (CAS 126-72-7)
- Nemonoxacin Impurity 91 (CAS CATO-C4X-312891)
- Venlafaxine EP Impurity B HCl (CAS 2174001-92-2)
- Empagliflozin Impurity 289 (CAS CATO-C4X-1065289)
- 2-(2-(2,3-Dichlorophenoxy)acetyl)-N-(4-methoxyphenyl)hydrazine-1-carbothioamide (CAS 1022591-04-3)
- 4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid (CAS 212578-38-6)
- 3-[(2-Piperidin-3-yl-1H-imidazol-1-yl)methyl]pyridine trihydrochloride (CAS 1993054-97-9)
- H-Arg-Arg-βNA · 3 HCl (CAS 100900-26-3)
- 4,4,5,5-Tetramethyl-2-(thiophen-3-ylmethyl)-1,3,2-dioxaborolane (CAS 1444010-65-4)
- 2-Bromo-4-methoxynicotinic acid (CAS 87853-67-6)
- D-β-Asp9-Tirzepatide (CAS CATO-CPTD788932)
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