Macitentan Impurity 23 CAS CATO-C4X-117523
| CAS No. | CATO-C4X-117523 |
| Molecular Formula | C19H20Br2N6O5S |
| Molecular Weight | 604.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 604.27 g/mol gives Macitentan Impurity 23 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Macitentan Impurity 23 (CAS CATO-C4X-117523, C19H20Br2N6O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H20Br2N6O5S, Macitentan Impurity 23 contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 604.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20Br2N6O5S |
| Molecular Weight | 604.27 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 22 (CAS CATO-C4X-117522)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
- Macitentan-d4 (CAS 1258428-05-5)
- Macitentan (CAS 441798-33-0)
- Macitentan Impurity 26 (CAS CATO-C4X-117526)
- Macitentan Impurity 24 (CAS 556797-16-1)
- Macitentan Impurity 2 (CAS 441796-13-0)
- Macitentan Impurity 1 (CAS 441798-25-0)
Recommended Standards
- (2-Butyl-3-benzofuranyl)[4-(2-hydroxyethoxy)-3,5-diiodophenyl]methanone (CAS 135048-44-1)
- 1-(3-(Perfluorooctyl)-5-phenyl-1H-pyrazol-1-yl)ethan-1-one (CAS 959583-89-2)
- 3,8-Bis[3,5-bis(trifluoromethyl)phenyl]-1,10-phenanthroline (CAS 1228032-35-6)
- 1-(3-(Perfluorooctyl)-5-phenyl-1H-pyrazol-1-yl)ethan-1-one (CAS 511243-94-0)
- Mometasone Impurity C84 (CAS 722495-06-9)
- Fluconazole Impurity 40 (CAS 206050-23-9)
- Benserazide Impurity 55 (CAS CATO-C4X-142755)
- 4-Bromo-2-isobutoxy-3-methoxypyridine (CAS 1620691-40-8)
- 2-Mesitylquinoline (CAS 81828-87-7)
- Benzyl (R)-2-methyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate (CAS 1393597-77-7)
- 3-pyrazin-2-yl-1,2,4-oxadiazole-5-carboxylic acid (CAS 1313815-37-0)
- N-Methyl-2-(thiophen-2-yl)-1,3-thiazole-4-carboxamide (CAS 400080-72-0)
- 224317-64-0 5-Chloro-2-(2-propynyloxy)benzenecarbaldehyde 7669AD C10H7ClO2 (CAS 224317-64-0)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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