Macitentan Impurity 47 CAS CATO-C4X-117547
| CAS No. | CATO-C4X-117547 |
| Molecular Formula | C22H17Br3N6O4 |
| Molecular Weight | 669.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Macitentan Impurity 47.
As a process- or degradation-related impurity, Macitentan Impurity 47 (CAS CATO-C4X-117547, C22H17Br3N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Macitentan Impurity 47 (C22H17Br3N6O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Macitentan Impurity 47 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H17Br3N6O4 |
| Molecular Weight | 669.12 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
Related Macitentan Standards
- Macitentan Impurity 22 (CAS CATO-C4X-117522)
- Macitentan Impurity 23 (CAS CATO-C4X-117523)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
- Macitentan-d4 (CAS 1258428-05-5)
- Macitentan (CAS 441798-33-0)
- Macitentan Impurity 26 (CAS CATO-C4X-117526)
- Macitentan Impurity 24 (CAS 556797-16-1)
- Macitentan Impurity 2 (CAS 441796-13-0)
Recommended Standards
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- Poly[2,5-bis(3-dodecylthiophen-2-yl)thieno[3,2-b]thiophene] (CAS 888491-18-7)
- Evocalcet Impurity 27 (CAS 1039631-63-4)
- Netupitant Impurity 30 (CAS CATO-C4X-122330)
- Venlafaxine Impurity 60 (CAS CATO-C4X-143460)
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- 1-(4-Methoxyphenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 338422-68-7)
- 2-Chloro-5-methoxy-[1,3]thiazolo[5,4-b]pyridine (CAS 1196154-04-7)
- 6,9-Bis(carboxymethyl)-3-(2-(dodecylamino)-2-oxoethyl)-11-oxo-3,6,9,12-tetraazatetracosan-1-oic acid (CAS 102836-55-5)
- 3-Bromo-4-(ethylsulfonyl)aniline (CAS 1248605-77-7)
- 4-Cyano-2-(difluoromethyl)-6-hydroxynicotinic acid (CAS 1806841-76-8)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com