Eltrombopag impurity 149 CAS CATO-C4X-1198149
| CAS No. | CATO-C4X-1198149 |
| Molecular Formula | C20H25N5O5 |
| Molecular Weight | 415.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 415.44 g/mol gives Eltrombopag impurity 149 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Eltrombopag impurity 149 (CAS CATO-C4X-1198149) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25N5O5 and a molecular weight of 415.44 g/mol.
Based on its molecular formula C20H25N5O5, Eltrombopag impurity 149 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 415.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25N5O5 |
| Molecular Weight | 415.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Eltrombopag Standards
- Eltrombopag Impurity 106 (CAS CATO-C4X-1198106)
- Eltrombopag impurity 147 (CAS CATO-C4X-1198147)
- Eltrombopag Impurity 133 (CAS CATO-C4X-1198133)
- Eltrombopag Impurity 103 (CAS CATO-C4X-1198103)
- Eltrombopag Impurity 73 (CAS CATO-C4X-119873)
- Eltrombopag Impurity 134 (CAS CATO-C4X-1198134)
- Eltrombopag Impurity 71 (CAS CATO-C4X-119871)
- Eltrombopag Impurity 108 (CAS CATO-C4X-1198108)
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