Posaconazole Impurity 159 CAS CATO-C4X-1208159
| CAS No. | CATO-C4X-1208159 |
| Molecular Formula | C30H27N3O5 |
| Molecular Weight | 509.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Posaconazole Impurity 159 (CAS CATO-C4X-1208159, C30H27N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Posaconazole Impurity 159 (C30H27N3O5) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Posaconazole Impurity 159 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H27N3O5 |
| Molecular Weight | 509.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Posaconazole Standards
- Posaconazole Impurity 58 (CAS CATO-C4X-120858)
- Posaconazole impurity 249 (CAS CATO-C4X-1208249)
- Posaconazole Impurity 1 (CAS 2243786-01-6)
- Posaconazole Impurity 2 (CAS 2243786-00-5)
- Posaconazole Impurity 3 (CAS 2243786-02-7)
- Posaconazole Impurity 4 (CAS 184177-83-1)
- Posaconazole Impurity 266 (CAS CATO-C4X-1208266)
- Posaconazole Impurity 30 (CAS CATO-C4X-120830)
Recommended Standards
- Amoxicillin Impurity 88 (CAS CATO-C4X-114888)
- (S)-2,2',2'',2'''-(2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (CAS 181065-46-3)
- Pyr-Phe-Leu-pNA (CAS 85901-57-1)
- 2,2',2'',2'''-(2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (CAS 123317-52-2)
- Norepinephrine Impurity 99 (CAS CATO-C4X-151499)
- Brigatinib Impurity 4 (CAS CATO-C4X-26454)
- Nabumetone Impurity 28 (CAS 6297-10-5)
- 3,3'-(2-Bromo-7-iodo-9H-fluorene-9,9-diyl)bis(propan-1-ol) (CAS 1315468-05-3)
- .alpha.,.alpha.-Dimethyl-3-piperidinemethanol 252723-21-0 (CAS 252723-21-0)
- Ethyl 2-(2-hydroxyethoxy)acetate (CAS 194870-76-3)
- 2-(Difluoromethyl)-3-fluoro-5-formylisonicotinonitrile (CAS 1804494-53-8)
- {[cis-4-fluoro-1-(thiophen-2-ylmethyl)pyrrolidin-2-yl]methyl}(methyl)amine (CAS 1820576-31-5)
- (2-(4-Bromophenyl)cyclopropyl)methanamine (CAS 1226233-35-7)
- Semaglutide Impurity 191 (CAS CATO-C4X-2226191)
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