Posaconazole impurity 249 CAS CATO-C4X-1208249
| CAS No. | CATO-C4X-1208249 |
| Molecular Formula | C19H19F2IO4S |
| Molecular Weight | 508.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Posaconazole impurity 249 (CAS CATO-C4X-1208249), a pharmacopoeial impurity reference standard (molecular formula C19H19F2IO4S, MW 508.32 g/mol) used for the identification and quantification of trace impurities in APIs.
Posaconazole impurity 249 (C19H19F2IO4S) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Posaconazole impurity 249 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19F2IO4S |
| Molecular Weight | 508.32 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Sulfur Atoms | 1 |
Related Posaconazole Standards
- Posaconazole Impurity 159 (CAS CATO-C4X-1208159)
- Posaconazole Impurity 58 (CAS CATO-C4X-120858)
- Posaconazole Impurity 266 (CAS CATO-C4X-1208266)
- Posaconazole Impurity 30 (CAS CATO-C4X-120830)
- Posaconazole Impurity 5 (CAS 345217-02-9)
- Posaconazole Impurity 87 (CAS CATO-C4X-120887)
- Posaconazole Impurity 1 (CAS 2243786-01-6)
- Posaconazole Impurity 2 (CAS 2243786-00-5)
Recommended Standards
- Lifitegrast Impurity 75 (CAS CATO-C4X-240975)
- 1-(3,5-Bis(trifluoromethyl)benzyl)-2-oxo-N-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide (CAS 338781-94-5)
- Methyl (E)-3-(2-chlorophenyl)-5-(2-(3-(2-chlorophenyl)-4-oxo-4,5-dihydroisoxazolo[4,5-c]pyridin-7-yl)vinyl)isoxazole-4-carboxylate (CAS 321433-78-7)
- 1-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (CAS 338781-99-0)
- Cefuroxime Impurity 58 (CAS CATO-C4X-124558)
- Roxatidine Impurity 30 (CAS CATO-C4X-121330)
- Voriconazole Impurity 69 (CAS CATO-C4X-136669)
- 5-Dihydro-19-nortestosterone (CAS 1434-85-1)
- 4,4,5,5-Tetramethyl-2-(4-methylbenzyl)-1,3,2-dioxaborolane (CAS 356570-52-0)
- 6-Amino-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 73778-92-4)
- Pyridin-4-amine 2-(benzo[d]isoxazol-3-yl)maleate (CAS 138249-03-3)
- 1-[4-(2,2-Difluoroethoxy)-3-fluorophenyl]-ethanone (CAS 1373865-62-3)
- 2-(Pyrrolidin-1-yl)propan-1-amine oxalate (CAS 2034207-82-2)
- Liraglutide (CAS 204656-20-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com