Tacrolimus Impurity 1 CAS CATO-C4X-13001
| CAS No. | CATO-C4X-13001 |
| Molecular Formula | C44H70NO13 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tacrolimus Impurity 1 (CAS CATO-C4X-13001) is a certified pharmaceutical impurity reference standard with the molecular formula C44H70NO13Li and a molecular weight of 827.98 g/mol.
The molecular framework of Tacrolimus Impurity 1 (C44H70NO13Li) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C44H70NO13 Li |
| Molecular Weight | 827.98 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus (CAS 104987-11-3)
- Tacrolimus EP Impurity A (CAS 104987-12-4)
- Tacrolimus EP Impurity I (CAS 104987-16-8)
- Tacrolimus Impurity 27 (CAS 104987-25-9)
- Tacrolimus EP Impurity E (CAS 104987-30-6)
- Tacrolimus Impurity 4 (CAS 109466-74-2)
- Tacrolimus Monohydrate (CAS 109581-93-3)
- Tacrolimus Impurity 31 (CAS 123719-19-7)
Recommended Standards
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- (4-phenoxyphenyl)magnesium bromide 21473-02-9 4-Phenoxyphenylmagnesium bromide (CAS 21473-02-9)
- 4-(2-Amino-6-chloropyrimidin-4-yl)butanoic acid (CAS 688782-59-4)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
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