Tacrolimus EP Impurity E CAS 104987-30-6
| CAS No. | 104987-30-6 |
| Molecular Formula | C44H71NO12 |
| Molecular Weight | 806.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Tacrolimus EP Impurity E is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 806.03 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Tacrolimus EP Impurity E (CAS 104987-30-6, C44H71NO12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Tacrolimus EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C44H71NO12 |
| Molecular Weight | 806.03 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus Impurity 59 (CAS CATO-C4X-130059)
- Tacrolimus impurity 61 (CAS CATO-C4X-130061)
- Tacrolimus Impurity 35 (CAS CATO-C4X-130035)
- Tacrolimus (CAS 104987-11-3)
- Tacrolimus Impurity 15 (CAS CATO-C4X-130015)
- Tacrolimus Impurity 17 (CAS CATO-C4X-130017)
- Tacrolimus EP Impurity F (CAS 1393890-33-9)
- Tacrolimus EP Impurity G (CAS 144490-63-1)
Recommended Standards
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- Lapatinib Impurity 8 (CAS 202198-16-1)
- Raltitrexed Impurity 10 (CAS CATO-C4X-138610)
- Sulbenicillin Impurity 2 (CAS CATO-C4X-23242)
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- (2-(Bromomethyl)-3-methylbutyl)cyclopentane (CAS 1496207-63-6)
- 5-Bromo-1-ethyl-3-iodo-1H-pyrrolo[2,3-c]pyridine (CAS 1690341-99-1)
- 2,2-difluoro-1-(1-isobutyl-1h-pyraZol-4-yl)ethanone (CAS 1245823-42-0)
- 5-((6-Methoxybenzo[d]thiazol-2-yl)amino)-5-oxopentanoic acid (CAS 436086-78-1)
- Insulin Detemir (CAS 169148-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com